TCC - Triclocarban

1. Product Information

Product Name Triclocarban

Common Name/Synonym TCC

Chemical Name 3,4,4'-Trichlorocarbanilide

IUPAC Name 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Molecular Formula C₁₃H₉Cl₃N₂O

Molecular Weight 315.6 g/mol

CAS Number 101-20-2

EC Number 202-924-1

2. Product Characteristics

Property	Specification
Appearance	White crystalline powder with faint odor
Antimicrobial Spectrum	Broad-spectrum; effective against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts, and viruses
Mechanism of Action	Inhibits microbial fatty acid synthesis and disrupts cell membrane integrity, leading to cell death
Stability	Stable to light and heat; chemically stable; does not decompose easily
Solubility	Slightly soluble in water (0.11 mg/L at 20-25°C); soluble in ethanol (10 g/L), isopropanol (10 g/L), dipropylene glycol (48 g/L), fatty alcohol polyglycol (100 g/L)

Physical & Chemical Data:

Melting Point: 254-256°C (decomposes)
Vapor Pressure (25°C): 3.6×10⁻⁹ mmHg / 4.8×10⁻⁷ Pa
Density: 1.53 g/cm³
Log Kow: 4.9
Decomposition Temperature: >250°C

3. Quality Standards

Parameter	Specification	Test Method
Appearance	White crystalline powder	Visual
Odor	Faint odor	Organoleptic
Purity (HPLC)	≥98.0% (Technical) / ≥99.0% (Pharma)	HPLC
Melting Range	254°C-256°C (decomposes)	Capillary Method
Moisture (Karl Fischer)	≤0.5%	KF Titration
Residue on Ignition	≤0.1%	Gravimetric
Heavy Metals (as Pb)	≤0.002%	Colorimetric
Arsenic (As)	≤0.0001%	AAS
Dioxin Impurities	Compliant with EU limits	GC-MS
Identification	IR spectrum matches reference standard	FTIR

Note: Pharmaceutical grade meets stricter specifications than technical grade. Custom specifications available upon request.

4. Antimicrobial Activity (MIC Values)

Microorganism	MIC (mg/L)	Microorganism	MIC (mg/L)
Trichophyton sp.	500	Chaetomium globosum	100
Bacillus subtilis ATCC 11774	35-50	Enterococcus faecalis ATCC 19433	50
Escherichia coli EHEC DSM 8579	1000	Lactobacillus fermentum ATCC 14931	50
Legionella pneumophila ATCC 33152	<10	Micrococcus luteus ATCC 7468	5-10
Mycobacterium ATCC 11758	<0.05	Salmonella choleraesuis DSM 4224	1000
Staphylococcus aureus ATCC 6538	10-50	Staphylococcus haemolyticus ATCC 29970	50

Note: Triclocarban shows extremely strong antimycobacterial activity with MIC <0.05 mg/L against Mycobacterium; significant antibacterial effect against Micrococcus luteus with MIC 5-10 mg/L.

5. Applications

5.1 Personal Care & Cosmetics

Bar Soap: Primary application for antibacterial deodorant
Shampoo/Shower Gel: Antibacterial cleansing
Hand Wash/Facial Cleanser: Daily antibacterial care
Beauty Serum/Acne Cream: Skincare antimicrobial
Shaving Foam: Shaving care
Toothpaste/Mouthwash: Oral antimicrobial
Laundry Detergent/Fabric Softener: Fabric antimicrobial
Wound Ointment: Wound care
Cosmetics: Preservative for beauty products
Maximum Permitted Concentration: 0.2% (w/w)

5.2 Household & Industrial

Antibacterial Dishwashing Detergent: Dish cleaning
Textile Antimicrobial Finishing: Fabric antibacterial treatment
Medical Disinfectants: Medical device disinfection
Fiber Textiles: Antibacterial treatment
Deodorant Products: Body odor and foot odor control

5.3 Special Efficacy

Deodorizing Effect: Particularly effective against skin bacteria that decompose perspiration and urine
Long-lasting Protection: Good affinity with skin proteins provides persistent antimicrobial effect

6. Regulatory Compliance & Safety

Certification/Regulation	Details
China Cosmetics Regulation	Technical Safety Standard for Cosmetics 2015 Edition: Maximum 0.2%; restricted to rinse-off products only
US FDA	September 2016: Banned in hand washes and body washes
Canada	Gradually phased out or explicitly banned
EU	Restricted use; must comply with relevant regulatory requirements

Toxicity Data:

Endpoint	Value
Acute Oral LD₅₀ (Rat)	>2000 mg/kg
Acute Oral LD₅₀ (Mouse)	>5000 mg/kg
Acute Dermal LD₅₀ (Rabbit)	10000 mg/kg
LC₅₀ (Rainbow trout, 96h)	0.12 mg/L
LC₅₀ (Fathead minnow, 96h)	0.092 mg/L
LC₅₀ (Water flea, 48h)	0.0077-0.020 mg/L

Safety Precautions:

Strongly lipophilic; capable of bioaccumulation and biomagnification in organisms
Highly toxic to aquatic organisms
May cause cancer, reproductive dysfunction, and developmental abnormalities in mammals
Can induce DNA damage in human liver cells
Gradually phased out or explicitly banned in cleansing and personal care consumer products in Canada and the United States

7. Packaging & Storage

Packaging: 25kg fiber drum (PE-lined) / 1kg aluminum foil bag; customized packaging available

Storage: Cool, dry place (≤25°C); sealed, protected from light; away from strong acids, strong bases, and oxidizers

Shelf Life: 24 months (unopened)

Transport: Handle as general chemical; load/unload carefully to prevent package damage

8. Key Advantages

Superior Antimicrobial Activity: MIC <0.05 mg/L against Mycobacterium; extremely strong antibacterial activity
Deodorizing Efficacy: Particularly effective against skin bacteria that decompose perspiration and urine
Long-lasting Effect: Good affinity with skin proteins provides persistent antimicrobial protection
Thermal Stability: Decomposes only above 254°C; compatible with high-temperature processing
Broad Spectrum Coverage: Inhibitory effects on bacteria, fungi, yeasts, and viruses