Triclosan - Lijie Bio

Product Name Triclosan

Common Name/Synonym Triclosan

Chemical Name 2,4,4'-Trichloro-2'-hydroxydiphenyl ether

IUPAC Name 5-Chloro-2-(2,4-dichlorophenoxy)phenol

Molecular Formula C₁₂H₇Cl₃O₂

Molecular Weight 289.5 g/mol

CAS Number 3380-34-5

EC Number 222-182-2

Property	Specification
Appearance	White fine crystalline powder with faint aromatic odor
Antimicrobial Spectrum	Broad-spectrum; effective against Gram-positive bacteria, Gram-negative bacteria, molds, yeasts, and viruses
Mechanism of Action	Non-ionic compound; adsorbs to bacterial cell wall, penetrates and reacts with cytoplasmic lipids and proteins causing irreversible denaturation
Stability	Low volatility at ambient temperature; stable below 280-290°C; only 2% decomposition after heating at 200°C for 14h; slight decomposition under UV light
Solubility	Slightly soluble in water (0.01 g/L at 20°C); readily soluble in ethanol, isopropanol, propylene glycol, ethyl acetate, and alkaline solutions

Physical & Chemical Data:

Parameter	Specification	Test Method
Appearance	White fine crystalline powder	Visual
Odor	Faint aromatic odor	Organoleptic
Purity (HPLC)	≥98.0% (Technical) / ≥99.0% (Pharma)	HPLC
Melting Range	56°C-58°C	Capillary Method
Moisture (Karl Fischer)	≤0.1%	KF Titration
Residue on Ignition	≤0.1%	Gravimetric
Heavy Metals (as Pb)	≤0.002%	Colorimetric
Arsenic (As)	≤0.0001%	AAS
Dioxin Impurities	Compliant with EU limits	GC-MS
Identification	IR spectrum matches reference standard	FTIR

Note: Pharmaceutical grade meets stricter specifications than technical grade. Custom specifications available upon request.

Microorganism	MIC (mg/L)	Microorganism	MIC (mg/L)
Staphylococcus aureus	0.01-0.1	Escherichia coli	0.1-1.0
Bacillus subtilis	0.01-0.1	Pseudomonas aeruginosa	0.5-5.0
Candida albicans	0.1-1.0	Aspergillus niger	1.0-10.0
Trichophyton mentagrophytes	0.1-1.0	Saccharomyces cerevisiae	0.5-5.0

Note: Triclosan shows particularly significant inhibition against Gram-positive bacteria with extremely low MIC values (0.01-0.1 mg/L)

5.1 Personal Care & Cosmetics

Oral Care: Toothpaste and mouthwash (maximum 0.3%)
Body Care: Soap, hand wash, shower gel, feminine hygiene wash
Skin Care: Premium skincare products, deodorant sprays for body odor/athlete's foot, wound disinfectants
Color Cosmetics: Face powders, concealers, nail cleansers (frequency not exceeding once per 2 weeks)
Maximum Permitted Concentration: 0.3% (w/w); prohibited for products contacting mucous membranes

5.2 Medical & Healthcare

Medical Device Disinfection: Disinfectants for medical and food industry instruments
Wound Treatment: Wound disinfectants and sanitary textile finishing
Air Freshening: Air fresheners and refrigerator deodorizers

5.3 Industrial & Household

Certification/Regulation	Details
China Cosmetics Regulation	Technical Safety Standard for Cosmetics 2015 Edition: Maximum 0.3%; restricted to hand soap, bath soap, body wash, deodorant (non-spray), face powder/concealer, and nail cleanser (frequency not exceeding once per 2 weeks)
EU Regulations	January 2014: Triclosan removed from Annex V of Regulation (EC) No. 1223/2009; restricted as cosmetic preservative; EU SCCS considers 0.3% maximum concentration safe in toothpaste, hand soap, soap/shower gel, and deodorant
US FDA	September 2016: Banned in hand washes and body washes; still permitted in toothpaste
Other Applications	Still permitted in non-cosmetic fields such as medical devices and industry

Toxicity Data:

Endpoint	Value
Acute Oral LD₅₀ (Rat)	>5000 mg/kg (Practically non-toxic)
Acute Dermal LD₅₀ (Rabbit)	>6000 mg/kg
Skin Irritation	No acute or chronic toxicity
Special Risks	Reacts with chlorine-containing bleaches to form toxic chlorinated derivatives; may produce carcinogenic substances upon UV exposure or heating

Precautions:

Packaging: 25kg fiber drum (PE-lined) / 1kg aluminum foil bag; customized packaging available

Storage: Cool, dry place (≤25°C); sealed, protected from light; away from chlorine-containing bleaches, strong acids, strong bases, and oxidizers

Shelf Life: 24 months (unopened)

Transport: Handle as general chemical; load/unload carefully to prevent package damage

Superior Antimicrobial Activity: MIC values as low as 0.01 mg/L against Gram-positive bacteria, outperforming most similar products
Excellent Stability: No decomposition below 280°C; compatible with high-temperature processing
Non-ionic Characteristic: Good affinity with skin proteins; compatible with various cosmetic raw materials
Historical Classic: Originally synthesized by Ciba-Geigy (Switzerland) with long application history and mature technology
Oral Care Specialist: Still the mainstream antimicrobial agent in toothpaste globally with comprehensive safety data