TCMTB - Thiocyanomethylthiobenzothiazole

I. Product Information

Product Name TCMTB

Synonyms Thiocyanomethylthiobenzothiazole

Chemical Name 2-(Thiocyanomethylthio)benzothiazole

IUPAC Name 1,3-benzothiazol-2-ylsulfanylmethyl thiocyanate

Molecular Formula C₉H₆N₂S₃

Molecular Weight 238.4

CAS No. 21564-17-0

EC Number 244-445-0

II. Product Properties

Property	Description
Appearance	Yellow crystals or oily liquid (pure); brown-red oily liquid (80% TC); available as 60% and 30% formulations
Antimicrobial Spectrum	Broad-spectrum efficacy against bacteria, molds, and yeast; especially effective against Aspergillus niger, Penicillium citrinum, Aspergillus flavus, Penicillium chrysogenum, Trichoderma, and most molds
Mechanism	Thiocyanate group reacts with microbial enzyme systems, inhibiting cellular respiration and energy metabolism
Stability	Decomposes under alkaline conditions; decomposes above 130°C; excellent stability to temperature, pH, and UV (when combined with glutaraldehyde)
Solubility	Water 0.03 g/L (slightly soluble); readily soluble in acetone, DMF, toluene; isopropanol <0.5 g/L; ethylene glycol <0.5 g/L; propylene glycol <0.5 g/L

Physical & Chemical Data:

Density (22℃): 1.38 g/mL (pure)
Vapor Pressure (25℃): 4.75×10⁻⁶ hPa / <0.01 mmHg (TC)
lgKow: 3.30
Flash Point: ≥120.7℃
DT₅₀ (Biodegradation in water): 2.8 days
Active Ingredient (TC): 80%

III. Quality Specifications

Test Item	Specification	Method
Appearance	Yellow crystals or oily liquid (pure) / Brown-red oily liquid (80% TC)	Visual
Active Ingredient	≥80% (TC) / 60%±2% (formulation) / 30%±1% (formulation)	GC
Density (22℃)	1.38 g/mL (pure)	Densitometry
Vapor Pressure (25℃)	4.75×10⁻⁶ hPa	Vapor Pressure Method
Flash Point	≥120.7℃	Closed Cup
Moisture	≤0.5%	Karl Fischer
pH Stability	Decomposes under alkaline conditions	pH Meter
Thermal Stability	Decomposes above 130°C	TGA
Biodegradability (DT₅₀)	2.8 days (water)	OECD 301B
Heavy Metals (as Pb)	≤0.002%	Colorimetric
Identification	IR spectrum matches reference standard	FTIR

Note: Available as 80% TC, 60% formulation, 30% formulation, and other custom specifications.

IV. Antimicrobial Performance (MIC Data)

Microorganism	MIC (mg/L)	Microorganism	MIC (mg/L)
Aspergillus niger	3	Bacillus megaterium	50
Aspergillus flavus	3	E. coli	20
Aspergillus versicolor	3	S. aureus	20
Chaetomium globosum	1	B. subtilis	50
Cladosporium herbarum	3	Pseudomonas fluorescens	50
Penicillium citrinum	3	P. aeruginosa	50 (4h) / 20 (24h)
Paecilomyces variotii	3	Saccharomyces cerevisiae	10
Trichoderma viride	20

Note: TCMTB shows excellent antifungal activity with MIC values of 1-3 mg/L against A. niger, A. flavus, and P. citrinum.

Synergistic Effect with Glutaraldehyde (vs P. aeruginosa):

Ratio (TCMTB:Glutaraldehyde)	MIC 4h (mg/L)	SI (Synergy Index)	MIC 24h (mg/L)	SI (Synergy Index)
19:1	90	1.29	40	0.64
9:1	80	1.20	40	0.71
4:1	50	1.00	40	0.85
1:1	20	0.63	20	0.64
1:4	20	0.85	20	0.85
1:9	10	0.46	20	0.92
TCMTB alone	80 (4h) / 70 (24h)	-	-	-
Glutaraldehyde alone	20	-	20	-

Note: SI<1 indicates synergy, SI=1 indicates additivity, SI>1 indicates antagonism; TCMTB and glutaraldehyde show significant synergistic effects at ratios 19:1 to 1:9, with optimal ratio 1:1 to 1:4.

V. Applications

1. Agriculture

Seed treatment: Cotton, corn, barley, rice, wheat, sorghum, sugar beet, and other crop seeds
Soil-borne disease control: Prevention and treatment of soil-transmitted diseases
Function: Protects seeds from mold and bacteria, improving germination rates and crop yields

2. Industrial Water Treatment

Cooling water systems: Microbial control in heat exchange systems, preventing biofouling, flow reduction, and increased energy consumption
Features: Low volatility, excellent stability to temperature, pH, and UV, compatible with other water treatment chemicals
Combined application: With glutaraldehyde (ratio 19:1 to 1:9, dosage 1-100 mg/kg), showing significant synergistic effects at 4h and 24h exposure

3. Leather Industry

Leather tanning: Prevents bacterial action during early stages (curing and soaking) and fungal action during later stages
Fur preservation: Short-term preservation of salt-free leather and fur; prevents bacterial damage to pickled or tanned leather products
Features: No adverse effects on leather quality; does not affect final product color or physical properties

4. Wood Preservation

Wood processing: Inhibits bacteria and fungi attacking wood
Surface coatings: Non-volatile; soluble in organic solvents or dispersible in water
Metal-friendly: Non-corrosive to steel and copper; no discoloration or staining; compatible with nitrocellulose lacquers and varnishes
Applications: Wood processing industry and surface coating sector

5. Papermaking Industry

Pulp preservation: Prevents microbial contamination
Anti-mold paper: Production of mold-resistant paper

6. Coatings Industry

Coating preservation: Anti-mold and antimicrobial protection for industrial coatings and paints
Features: Does not affect coating color or gloss

VI. Regulatory Compliance & Safety

Certification/Regulation	Details
Toxicity Data (TC)	Rat acute oral LD₅₀: 2664 mg/kg; Rabbit acute dermal LD₅₀: 2000 mg/kg
Sub-chronic Toxicity	Rat sub-chronic oral NOEL: 500 mg/kg; Dog sub-chronic oral NOEL: 333 mg/kg
Teratogenic/Mutagenic/Carcinogenic	No teratogenic, mutagenic, or carcinogenic effects observed at test doses
Skin Irritation	Irritating to rabbit eyes and skin
Aquatic Toxicity	Carp LC₅₀ (48h): 0.125-0.25 mg/L; Rainbow trout LC₅₀ (96h): 0.029 mg/L
Biodegradability	DT₅₀ (water): 2.8 days; readily biodegradable
Environmental Profile	Rapid degradation in water; environmentally friendly

Safety Precautions:

Irritating to eyes and skin; wear protective equipment during handling
Highly toxic to aquatic organisms; avoid direct discharge into water bodies
Decomposes under alkaline conditions; avoid mixing with strong alkalis

VII. Packaging & Storage

Packaging: 200kg/iron drum (TC) / 25kg/plastic drum (formulations); custom sizes available

Storage: Cool, dry place (≤25°C), sealed, away from light; avoid strong alkalis and oxidizers

Shelf Life: 24 months (sealed)

Transport: Hazardous chemical (irritant, aquatic environmental hazard); handle with care

VIII. Key Advantages

Excellent mold control: MIC 1-3 mg/L against A. niger, A. flavus, and P. citrinum
Synergistic enhancement: Significant synergistic effects with glutaraldehyde at ratios 19:1 to 1:9, optimal at 1:1 to 1:4
Industrial compatibility: Non-corrosive to steel and copper; no discoloration or staining; suitable for metal processing
Rapid degradation: DT₅₀ only 2.8 days in water; environmentally friendly with no persistent pollution
Broad applications: Covers agriculture, water treatment, leather, wood, papermaking, and coatings
Good stability: Excellent stability to temperature, pH, and UV; suitable for industrial environments