PCMX - Chloroxylenol

Product Name 4-Chloro-3,5-dimethylphenol

Common Name PCMX / Chloroxylenol

IUPAC Name 4-Chloro-3,5-dimethylphenol

Synonyms Chloroxylenol; p-Chloro-m-xylenol

Molecular Formula C₈H₉ClO

Molecular Weight 156.6 g/mol

CAS Number 88-04-0

EC Number 201-793-8

Property	Specification
Appearance	White crystalline powder with slight phenolic odor
Antimicrobial Spectrum	Broad-spectrum; effective against 160+ bacteria, viruses, and fungi
Safety Profile	FDA-approved topical antimicrobial; low toxicity, non-irritating
Stability	Stable at ambient temperature; steam-volatile; stable in hot water
Solubility	Soluble in ethanol, isopropanol, benzene, and alkaline solutions

Physical & Chemical Data:

Quality standards based on industrial and pharmaceutical grades:

Parameter	Specification	Test Method
Appearance	White to off-white crystalline powder	Visual
Purity (GC)	≥98.5% (Technical) / ≥99.0% (Pharma)	Gas Chromatography
Melting Range	114°C - 116°C	Capillary Method
Moisture (Karl Fischer)	≤0.5%	KF Titration
Residue on Ignition	≤0.1%	Gravimetric
Iron (Fe)	≤100 ppm (Tech) / ≤50 ppm (Pharma)	AAS
Copper (Cu)	≤100 ppm	AAS
Total Impurities	≤1.5%	GC
3,5-Xylenol (MX)	≤0.5%	GC
2-Chloro-3,5-xylenol (OCMX)	≤0.3%	GC
2,4-Dichloro-3,5-xylenol (DCMX)	≤0.3%	GC
Tetrachloroethylene	≤0.1%	GC
Identification	IR spectrum matches reference standard	FTIR

Note: Pharmaceutical grade meets stricter specifications. Custom grades available upon request.

Microorganism	MIC (mg/L)	Microorganism	MIC (mg/L)
Aspergillus niger	50	Mucor mucedo	50
Aspergillus flavus	50	Bacillus subtilis	50
Aspergillus versicolor	50	Bacillus megaterium	50
Penicillium citrinum	50	Escherichia coli	250
Paecilomyces variotii	100	Pseudomonas fluorescens	>1000
Cladosporium cladosporioides	50	Staphylococcus aureus	50
Trichoderma viride	50	Pseudomonas aeruginosa	>1000
Chaetomium globosum	50	Saccharomyces cerevisiae	50
Alternaria alternata	50	Candida albicans	100

Note: MIC determined by broth dilution method (liquid shake culture)

5.1 Pharmaceutical & Medical

5.2 Household & Institutional Sanitization

5.3 Industrial Preservation

Coatings: Fungicide for humid environments
Metalworking fluids: Prevents microbial growth, odor, and corrosion
Leather processing: Antifungal treatment (salted hides, vegetable-tanned leather)
Textiles: Antimicrobial finishing agent
Adhesives: Prevents microbial decomposition

Endpoint	Value
Acute Oral LD₅₀ (Rat)	3830 mg/kg (Low toxicity)
Acute IP LD₅₀ (Mouse)	115 mg/kg
Acute Dermal LD₅₀ (Rat)	>2000 mg/kg
LC₅₀ (Rainbow trout, 96h)	0.76 mg/L
EC₅₀ (Water flea, 48h)	7.7 mg/L
Skin Irritation	Non-irritating (at appropriate concentrations)
Sensitization	Non-sensitizing

Packaging: 25kg fiber drum (PE-lined) / 1kg aluminum foil bag

Storage: Cool, dry place (≤25°C); sealed, protected from light; away from ignition sources and oxidizers

Shelf Life: 36 months (unopened)

Handling: Avoid rough handling to prevent package damage and moisture absorption

Regulatory Status: FDA-approved topical antimicrobial; no known resistance development
Broad Spectrum: Effective against 160+ microorganisms, particularly Gram-positive bacteria
Safety Profile: Low toxicity and irritation; suitable for skin-contact products
Stability: Stable under ambient storage; compatible with liquid, powder, and cream formulations
Versatility: Covers pharmaceutical, personal care, and industrial applications

PCMX (Chloroxylenol)